Publications

• Stephan Baehr, Wei-Chin Ho, Samuel Perez, Alyssa Cenzano, Katelyn Hancock, Lea Patrick, Adalyn Brown, Samuel Miller & Michael Lynch (2025) Consideration of a liquid mutation-accumulation experiment to measure mutation rates by successive serial dilution. Genome Biol. Evol. 17(4): evaf049. Link

• Megan G. Behringer, Wei-Chin Ho, Samuel F. Miller, Sarah B. Worthan, Zeer Cen, Ryan Stikeleather & Michael Lynch (2024) Trade-offs, trade-ups, and high mutational parallelism underlie microbial adaptation during extreme cycles of feast and famine. Curr. Biol. 34(7): 1403-1413. Link

• Wen Wei*, Wei-Chin Ho*, Megan G. Behringer, Samuel F. Miller, George Bcharah & Michael Lynch (2022) Rapid evolution of mutation rate and spectrum in response to environmental and population-genetic challenges. Nat. Comm. 13:4752. Link

• Leandra Brettner, Wei-Chin Ho, Kara Schmidlin, Sam Apodaca, Rachel Eder & Kerry Geiler-Samerotte (2022) Challenges and potential solutions for studying the genetic and phenotypic architecture of adaptation in microbes. Curr. Opin. Genet. Dev. 75:101951. Link

• Megan G. Behringer*, Wei-Chin Ho*, John C. Meraz, Samuel F. Miller, Gwyneth F. Boyer, Carl J. Stone, Meredith Andersen & Michael Lynch (2022) Complex ecotype dynamics evolve in response to fluctuating resources. mBio 13(3):e0346721. Link

• Wei-Chin Ho, Megan G. Behringer, Samuel F. Miller, Jadon Gonzales^, Amber Nguyen^, Meriem Allahwerdy^, Gwyneth Boyer & Michael Lynch (2021) Evolutionary dynamics of asexual hypermutators adapting to a novel environment. Genome Biol. Evol. 13(12):evab257. Link

• Wei-Chin Ho*, Diyan Li*, Qing Zhu & Jianzhi Zhang (2020) Phenotypic plasticity as a long-term memory easing readaptations to ancestral environments. Sci. Adv. 6(21): eaba3388. Link

• Michael Lynch & Wei-Chin Ho (2020) The limits to estimating population-genetic parameters with temporal data. Genome Biol. Evol. 12(4): 443–455. Link

• Wei-Chin Ho & Jianzhi Zhang (2019) Genetic gene expression changes during environmental adaptations tend to reverse plastic changes even after the correction for statistical nonindependence. Mol. Biol. Evol. 36(3): 604–612. Link

• Wei-Chin Ho & Jianzhi Zhang (2018) Evolutionary adaptations to new environments generally reverse plastic phenotypic changes. Nat. Comm. 9: 350. Link

• Wei-Chin Ho, Yoshikazu Ohya & Jianzhi Zhang (2017) Testing the neutral hypothesis of phenotypic evolution. Proc. Natl. Acad. Sci. U.S.A. 114(46): 12219-12224. Link

• Calum J. Maclean*, Brian P.H. Metzger*, Jian-Rong Yang*, Wei-Chin Ho, Bryan Moyers & Jianzhi Zhang (2017) Deciphering the genic basis of yeast fitness variation by simultaneous forward and reverse genetics. Mol. Biol. Evol. 34(10): 2486-2502. Link

• Wei-Chin Ho & Jianzhi Zhang (2016) Adaptive genetic robustness of Escherichia coli metabolic fluxes. Mol. Biol. Evol. 33(5): 1164-1176. Link

• Wei-Chin Ho & Jianzhi Zhang (2014) The genotype-phenotype map of yeast complex traits: basic parameters and the role of natural selection. Mol. Biol. Evol. 31(6): 1568-1580. Link

(*co-first authors; ^undergraduate mentees.)